A form of the anticancer drug irinotecan that is contained in very tiny, fat-like particles. It may have fewer side effects and work better than irinotecan alone. SN-38 liposome is being studied in the treatment of advanced colorectal cancer and other types of cancer. SN-38 liposome blocks the ability of cells to divide and grow. It may stop the growth of tumor cells. It is a type of topoisomerase inhibitor and a type of irinotecan (CPT-11) derivative. Also called liposomal SN-38.