A regimen consisting of rituximab, followed by a continuous infusion of etoposide, vincristine and doxorubicin, given with prednisone and a bolus dose of cyclophosphamide, used for the treatment of aggressive forms of non-Hodgkin's lymphoma, including mantle cell lymphoma. or An abbreviation for a chemotherapy combination used to treat certain types of non-Hodgkin lymphoma. It includes the drugs rituximab, etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, and doxorubicin hydrochloride (hydroxydaunorubicin). Also called R-EPOCH.