“anti-transthyretin siRNA ALN-TTR02”的概念、定义、翻译、参考文献-科学参考

A lipid nanoparticle (LNP)-based formulation consisting of small-interfering RNAs (siRNAs) directed against transthyretin (TTR)-encapsulated in lipids, which has potential use in the treatment of TTR-mediated amyloidosis (ATTR). Upon intravenous administration of ALN-TTR02, the lipid formulation promotes the uptake by cells. The siRNAs bind to TTR mRNAs, which may result in the inhibition of both the translation and expression of the TTR protein. ATTR is caused by mutations in the TTR gene and results in the formation of abnormal amyloid proteins that accumulate in and cause damage to various body organs and tissues.

单词	anti-transthyretin siRNA ALN-TTR02
释义	anti-transthyretin siRNA ALN-TTR02 A lipid nanoparticle (LNP)-based formulation consisting of small-interfering RNAs (siRNAs) directed against transthyretin (TTR)-encapsulated in lipids, which has potential use in the treatment of TTR-mediated amyloidosis (ATTR). Upon intravenous administration of ALN-TTR02, the lipid formulation promotes the uptake by cells. The siRNAs bind to TTR mRNAs, which may result in the inhibition of both the translation and expression of the TTR protein. ATTR is caused by mutations in the TTR gene and results in the formation of abnormal amyloid proteins that accumulate in and cause damage to various body organs and tissues.
随便看	nephroureterectomy Neptazane neratinib neritic zone nerve nerve nerve block nerve cell nerve fiber nerve grafting nerve growth factor nerve impulse nerve-sparing radical prostatectomy nerve-sparing surgery nervous system nervous system NES nesiritide nesvacumab netazepide Net force net primary production net primary productivity (NPP) net productivity netupitant