“anti-nucleolin aptamer AS1411”的概念、定义、翻译、参考文献-科学参考

A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411 targets and binds to nucleolin, a nucleolar phosphoprotein which is overexpressed on the surface of certain cancer cells. Via binding to cell surface nucleolin, AS1411 is internalized and may prevent nucleolin from binding to and stabilizing mRNA of the anti-apoptotic BCL2, thereby destabilizing BCL2 mRNA, leading to a reduction in BCL2 protein synthesis. This may lead to the induction of apoptosis.

单词	anti-nucleolin aptamer AS1411
释义	anti-nucleolin aptamer AS1411 A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411 targets and binds to nucleolin, a nucleolar phosphoprotein which is overexpressed on the surface of certain cancer cells. Via binding to cell surface nucleolin, AS1411 is internalized and may prevent nucleolin from binding to and stabilizing mRNA of the anti-apoptotic BCL2, thereby destabilizing BCL2 mRNA, leading to a reduction in BCL2 protein synthesis. This may lead to the induction of apoptosis.
随便看	investigator inviable Invirase in vitro in vitro fertilization in vitro fertilization involuntary involuntary nervous system INxin iobenguane I 123 iobenguane I 131 iobenguane scan iobitridol iodinated contrast dye iodine iodine-123 metaiodobenzylguanidine iodine 131-6-beta-iodomethyl-19-norcholesterol iodine I 123 iodine I 123 ADAM iodine I 123 anti-CEA recombinant diabody T84.66 iodine I 123 iodobenzamide iodine I 123 iodometomidate iodine I 123 metaiodobenzylguanidine iodine I 124 iodine I 124 CPD-1028