“PARP 1/2 inhibitor E7449”的概念、定义、翻译、参考文献-科学参考

An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA. Check for active clinical trialsusing this agent.

单词	PARP 1/2 inhibitor E7449
释义	PARP 1/2 inhibitor E7449 An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA. Check for active clinical trialsusing this agent.
随便看	binding agent Binding energy Binding energy binimetinib binomial Binosto bioactive compound bioavailable biochanin A biochemical pathway biochemical reactions biochemical recurrence biochemical relapse biochemist biodiversity hotspot bioenergetics biofeedback biofilm biogeochemical cycles biogeography bioinformatics biologic agent biological biological agent biological clock